San Paolo (Giuseppe De Liguoro, Rodolfo Kanzler, Milano Film, 1910) narrates the highlights of the life of Saint Paul, a religious subject based on the Acts of the Apostles. In its settings it intersects with the representation of the classical world in the first century CE, tracing a geographical and historical arc from an imaginatively conceived Asia Minor (Tarsus) and Syria (Damascus) to Neronian Rome during the Great Fire of 64 CE. This analysis explores the various surviving versions of the film, as well as its notable use of on-location settings and colour as a means of reinforcing the authenticity of Paul’s presence in Rome and its religious resonance. The film is a pioneering work in which a hugely significant historical-religious narrative meets the merging grammar of silent cinema.